Some new stuff to play with, synergies between skills, new cube recipies and new items. They randomized the monsters a bit on Hell difficulty, you'll find more and different monsters in some areas. More resistence was given to monsters, especially the 50% physical resistance bites if you're playing a barb on Hell difficulty. Quite a few drops were nerfed (Mephisto and Pindle to name the two best known), which makes item hunting a bit more difficult.
I found that playing with my barb or amazon became frustrating because the setup they have works pretty good in 1.09, but is not good enough for 1.10.
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